Generic: Dobutamine HCl

Class: Inotropic agent

Indications: lnotropic support of the myocardium in the treatment of acute congestive heart failure or cardiogenic shock

Dosage: The usual dose is 2.5 – 10 μg/kg/minute. On rare occasions, infusion rates up to 40 μg/kg/minute have been required to obtain the desired effect. The dosage should be adjusted individually according to the patient’s heart rate and rhythm, blood pressure and diuresis. Partial tolerance may develop if infusion time exceeds 72 hours, and such cases may call for an increase in dosage.

For infusion: the sterile solution for injection is diluted in physiological sodium chloride or glucose (glucose physiology) solution. When stored at room temperatures not exceeding 30°C, the prepared infusion solution should be used within 12 hours, and when stored in a refrigerator (2 to 8°C), within 24 hours. Dobutamine should not be diluted in alkaline solutions and should not be used in conjunction with other drugs or diluents containing both sodium bisulfite and ethanol.

Contraindications: Hypersensitivity to sulphitesidiopathic hypertrophic subaortic stenosis or with known hypersensitivity to the drug or any ingredient in the formulation

Precautions: Continuous monitoring of ECG and BP. Hypovolemia, dermal necrosis. Do not dilute in strongly alkaline solution. Pregnancy Risk Category B

Side Effects: Ectopic heartbeats, increased heart rate, angina, elevated blood pressure, headache, nausea, vomiting, paresthesia, dyspnea

Drug Interactions: ß-adrenergic blockers, general anesthesia, heparin, sodium bicarbonate, cefazolin, penicillin, aminophylline, furosemide, thiopental sodium.

Elimination

The plasma half life of dobutamine is about 2 minutes.

Manufacturer: PT Ferron Par Pharmaceuticals

Country of Origin: Indonesia

Storage Condition: Store al temperatures not exceeding 30°C. Protect from light. Do not refrigerate.

Packaging: Solution for infusion 50 mg/mL x 5 mL amp . Price: Php 550