Class: Calcium Channel Blocker

Therapeutic Indications: Nicardipine 10mg/10mL solution for injection is indicated for the treatment of acute life-threatening hypertension,
particularly in the event of:
• Malignant arterial hypertension / Hypertensive encephalopathy
• Aortic dissection, when short-acting beta-blocker therapy is not suitable, or in combination with beta-blocker when beta-blockade alone is not
effective.
• Severe pre-eclampsia, when other intravenous antihypertensive agents are not recommended or are contraindicated.
• For the treatment of post-operative hypertension.

Dosage & Administration: The dosage regimen to achieve the desired blood pressure can vary depending on the targeted blood pressure, the
response of the patient, and the age or the status of the patient. Unless given by a central venous line, dilute to a concentration of 0.1 – 0.2
mg/mL before use.

Adults Initial Dose: Treatment should start with the continuous administration of nicardipine at a rate of 3-5 mg/hr for 15 minutes. Rates can
be increased by increments of 0.5 or 1 mg every 15 minutes. The infusion rate should not exceed 15mg/h.
Maintenance dose: When the target pressure is reached, the dose should be reduced progressively, usually to between 2 and 4mg/hr to
maintain the therapeutic efficacy.

Precautions: Cardiac failure, ischemic cardiovascular disease, pregnancy, patients with history of hepatic dysfunction, patients with portal
hypertension, patients with pre-existing elevated intracranial pressure, combination with beta-blockers, pediatric population.

Undesirable Effects: The most frequent events are headache, dizziness, peripheral edema, palpitations, and flushing.

Drug Interactions: Nicardipine may enhance the negative inotropic effect of beta-blockers and may cause heart failure in patient with latent or
uncontrolled heart failure. Dantrolene, Magnesium, CYP3A4 inducers and inhibitors, Cyclosporine, tacrolimus, and sirolimus, Digoxin.

Packaging: Solution for IV infusion 1mg/mL x 10 mL amber glass ampoule

FDA Reg. No: DRP-8121-07

Manufacturer: Alwin DMD Pharmaceutical, India